Impact of Exercise Training Intensity on Abdominal Visceral Fat and Risk Factors Associated With the Metabolic Syndrome

Launched by UNIVERSITY OF VIRGINIA · Jul 6, 2006

Keywords

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Volunteers must have meet the definition of the metabolic syndrome (based on IDF consensus statement).
• • Screening biochemical tests of liver, kidney, hematologic, metabolic (below) and thyroid function must be normal.
• * The volunteer must be willing to:
• • 1. visit the outpatient GCRC or clinic once monthly for 16 weeks of intervention,
• • 2. participate in supervised exercise training (if assigned) and
• • 3. enter the inpatient GCRC for 2-3 days of more intensive studies at baseline and after 16 weeks of intervention. The subject must provide voluntary and fully informed written consent.
• Exclusion Criteria:
• • Type 1 diabetes,
• • drug or alcohol abuse,
• • psychosis,
• • severe or untreated depression,
• • dementia, polycythemia (hematocrit \> 55%),
• • clinically symptomatic coronary artery,
• • pulmonary or orthopedic disease (which would disallow exercise training),
• • history of vascular or peripheral nerve trauma,
• • lymph node dissection,
• • anemia, uncontrolled hypertension (\> 160/105 untreated or \> 145/95 treated),
• • allergic to octafluoropropane, or nitroglycerine,
• • weight loss or gain of 2 kg or more within the preceding 10 days,
• • investigational drug use within five biological half-lives,
• • treatment with ACE inhibitors or ARBs, thiazolindiones,
• • 1st or 2nd generation anti-psychotics insulin, or Viagra,
• • unwillingness to provide written informed voluntary consent,
• • pregnant, breast feeding or use hormonal birth control.