Zinc-ORS in Severe and Complicated Acute Diarrhea

Launched by CENTRE FOR INTERNATIONAL HEALTH · Aug 31, 2006

Keywords

ClinConnect Summary

Zinc deficiency is prevalent in developing countries due to inadequate food intake, low intake of foods from animal sources and high dietary intake of phytate, a substance that reduces zinc absorption. A recently completed trial at All India Institute Of Medical Sciences (AIIMS) measured the effect of zinc-ORS in the community, where most episodes are relatively mild. Zinc-ORS was efficacious in reducing the total number of stools (19% relative risk reduction, 95% CI 15% to 23%) and duration of diarrhoea (11% relative risk reduction, 95% CI 4% to 24%). In order to make policy decisions that...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Males
• * Age 1 month up to 36 months:
• • Passage of 3 or more liquid stools in a 24-hour period, every day, and at least one in 12 hours prior to admission
• • Diarrhea for \< 7days (168 hours)
• Exclusion Criteria:
• • severe systemic illness requiring intensive care management; systemic infection will be suspected if there is a general appearance of non-wellbeing with one or more of the following symptoms: shrill cry and irritability, temperature instability, hypotension, hypoglycemia, altered sensorium, lethargy or refusal of feeds, abdominal distension.
• • chronic illness like Tuberculosis, Nephrotic syndrome, malignancy etc or any surgical disorder.
• • severe malnutrition (weight for age \<65% of NCHS median
• • gross blood in stool
• • refusal of consent