Identifying Genetic Causes of IC/BPS

Launched by BOSTON CHILDREN'S HOSPITAL · Oct 17, 2006

Keywords

ClinConnect Summary

This clinical trial is looking into the genetic causes of interstitial cystitis (IC), bladder pain syndrome (BPS), and chronic pelvic pain syndrome (CPPS). These conditions can cause ongoing pelvic pain and frequent urination, yet the exact reasons for them remain unclear. Researchers believe that genetics may play a role, as studies with twins and families suggest these conditions could be inherited. By collecting genetic samples and medical information from individuals and their families in North America, the trial aims to identify any genetic factors that might be linked to these painful conditions.

If you or a family member has been diagnosed with IC, BPS, or CPPS, you may be eligible to participate in this study. The trial is open to people of all ages, starting from 7 years old, and welcomes both males and females. To join, participants should have symptoms like frequent urination (more than once an hour), pelvic pain lasting three months or longer, or discomfort when urinating. Participants will provide genetic samples and medical history, and they may also include family members who do or do not have symptoms. This study is currently recruiting, and your involvement could help uncover important insights into these conditions, possibly leading to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of IC/BPS
• • Males and females of any age
• • Urinary frequency - more than 1X/hour, and/or
• • Dysuria, and/or
• • Pelvic, suprapubic, or abdominal pain - for 3 months or longer
• • Nocturia
• • Normal urinary stream (by history)
• • No evidence of active bacterial UTI (no pyuria \& negative urinary culture for last 3 months)
• • First degree relative of someone with above symptoms
• Exclusion Criteria:
• • Major structural/anatomical urinary tract abnormalities by ultrasound
• • Underlying inborn conditions affecting the urinary tract
• • Surgery/chemotherapy affected pelvic area
• • GI or GU cancers
• • Severe Constipation in children only