Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)

Launched by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) · Oct 21, 2006

Keywords

ClinConnect Summary

Objective. Cardiac surgery is the leading cause of iatrogenic stroke in the United States; 1% to 5% of patients undergoing CABG have a stroke, and 30% have clinically silent new lesions that are detectable only on MRI. Cognitive dysfunction is also common after heart surgery, and up to 40% have long-term cognitive impairment. The primary objective of this study is to define the pre-operative risk profile that best predicts postoperative ischemic or cognitive changes in patients undergoing heart surgery and to 1) establish a registry of patients undergoing cardiac surgery to evaluate the rel...

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Eligibility criteria

• * INCLUSION CRITERIA:
• • Age 18 years or greater
• • Neurologically and cognitively independent prior to surgery (mRS less than 2)
• • CABG, aortic or mitral valve replacement, or a combined valve/CABG procedure scheduled within one week
• EXCLUSION CRITERIA:
• • Planned concomitant carotid endarterectomy
• • Concomitant medical disorders making clinical follow-up of at least 6 months unlikely or impossible (e.g., neoplastic disease, hepatic failure)
• • History of dementia, cognitive dysfunction (MMSE score less than 24) or psychotic disorder
• • Any current MRI contraindication (cardiac pacemaker or defibrillator, insulin pump, aneurysmal clip, implanted neural stimulator, cochlear implant, metal shrapnel or bullet, etc)
• • Definite or possible pacemaker placement at the time of or after surgery
• • Inability to give informed consent
• • Pregnancy