A Randomised, Controlled Comparison of Vitamin D Strategies is Acute Hip Fracture Patients

Launched by MCMASTER UNIVERSITY · Jan 17, 2007

Keywords

ClinConnect Summary

Low Vitamin D levels can cause faster bone loss and increase the risk of having a fracture. Patients who experience a hip fracture have low levels of Vitamin D. It is not clear how much Vitamin D must be taken in order to reach this optimal level.

Serum 25-hydroxyvitamin D3 (25-OHD) concentrations are the recognized functional status indicator for vitamin D. Although there is no clear consensus, vitamin D 'insufficiency' has been considered in the range of 25- 75/80 nmol/L. Patients with acute hip fracture are at high risk for a recurrent hip fracture or other fragility fractures (and fall...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Fragility hip fracture patient
• • Previous Vitamin D supplementation is okay.
• Exclusion Criteria:
• • Patients with pathological fracture secondary to malignancy or intrinsic bone disease (eg. Paget's disease)
• • Cancer in the past 10 years likely to metastasize to bone
• • Renal insufficiency (creatinine \<30 mls/min)
• • Hypercalcemia (primary hyperparathyroidism; granulomatous diseases; drug-induced such as lithium, thiazides), hypocalcemia, hypercalciuria, fracture or stroke within the last 3 months
• • Hormone replacement therapy, calcitonin, fluoride, or bisphosphonates during the previous 24 months
• • Pre-existing bone abnormality
• • Renal stones in past 10 years