Physical and Behavioral Traits of Overweight and Obese Adults

Launched by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK) · Jan 29, 2007

Keywords

ClinConnect Summary

**Trial Summary: Physical and Behavioral Traits of Overweight and Obese Adults**

This clinical trial is studying the physical and behavioral traits of adults who are overweight or obese, as well as those who have a healthy weight. Researchers want to understand how factors like hormones, metabolism, food preferences, fitness levels, sleep habits, and even thought processes differ between these groups. To do this, they will collect genetic material and conduct a variety of tests, which will include physical exams, blood tests, and assessments of body composition. Participants will also keep track of their food intake for a week and undergo tests to measure how their bodies respond to meals and exercise.

If you're over 18 years old and reasonably healthy, you might be eligible to participate. Specifically, you can qualify if you’re considered obese (with a Body Mass Index, or BMI, over 30), overweight (BMI between 25 and 30), or have a normal weight (BMI between 18.5 and 25). Participants will undergo several tests, including measurements of body fat and muscle, metabolic rate, and cognitive function. However, if you have certain health conditions, are pregnant, or have a history of significant medical issues, you may not be eligible. This study aims to gather important information that could help in understanding obesity better and how it relates to overall health.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• Obese subjects:
• • 1. Obese men and women over the age of 18 years;
• • 2. BMI greater than 30;
• Overweight subjects:
• • 1. Overweight men and women over the age of 18 years;
• • 2. BMI greater than 25 and less than 30
• Control subjects (may be matched for age, sex and years of education):
• • 1. Normal weight men and women over the age of 18 years;
• • 2. BMI greater than 18.5 and less than 25
• EXCLUSION CRITERIA:
• • 1. Patients with significant physical limitations that may preclude them from completing the majority of the tests in this study.
• • 2. Current, unstable medical conditions including cardiac ischemia; severe respiratory insufficiency requiring oxygen therapy; hepatic or cardiac failure as assessed by history and physical exam;
• • 3. Any psychiatric condition that would preclude participation in the study;
• • 4. Patients unwilling or unable to give informed consent.
• • 5. Pregnant women
• Additional exclusion for lean control subjects:
• • 1. Previous history of obesity as an adolescent or adult;
• • 2. Current or past history of eating disorders such as anorexia nervosa or bulimia.
• Exclusions for both cannabis users and controls:
• • 1. Dependence on drugs other than nicotine, caffeine and cannabis, within the past 6 months
• • 2. Any history of intravenous illegal drug use
• • 3. Alcohol use of more than 5 drinks per day, on 3 or more days in a week; or more than 15 drinks per week
• • 4. History of hepatitis B or C or current hepatitis A, B or C, or other liver disease associated with steatosis
• • 5. HIV
• • 6. History of diabetes (type 1 or type 2) or polycystic ovary disease or other conditions that may confound our study results
• • 7. Professional or collegiate athletes or participation in more than 60 minutes per day of vigorous exercise
• • 8. Use of prescribed or over the counter or herbal/alternative medications/ preparations with effects on glucose and lipid metabolism other than oral contraceptives
• • 9. Pregnancy or lactation
• • 10. Any condition or physical attribute which would interfere with MRI study e.g. claustrophobia, cochlear implant, metal fragments in the eye, certain types of tattoos or other metal implanted in the body