Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Feb 28, 2007

Keywords

ClinConnect Summary

The clinical trial titled "Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers" is being conducted by the Hematology Branch of the National Heart, Lung, and Blood Institute. This study aims to collect samples from healthy individuals to help researchers better understand how blood cells are formed, investigate viral blood diseases, explore the immune system's role in certain conditions, and identify genetic factors linked to blood disorders like aplastic anemia.

Anyone aged 8 years and older who considers themselves healthy may be eligible to participate. Participants will be asked to donate blood (about 4 tablespoons) from a vein in their arm, a sample of cells from the inside of their cheek using a gentle brush, and, if they are 18 or older, a sample of bone marrow taken from the hip bone with a local anesthetic to minimize discomfort. The study is currently recruiting participants, and it’s important to note that individuals who are pregnant or have certain health issues may not be eligible. This research is vital for advancing our knowledge of blood health and related diseases, and your participation could make a significant difference!

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Self-declared healthy volunteer (for blood and buccal mucosa sample donors).
• • Be healthy, as determined by Principal Investigator or designee based on recent (\<3 months) history, physical and laboratory results (for bone marrow and skin tissue sample donors).
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• • Age 8 years and older (no upper limit) for blood and buccal mucosa sampling.
• • OR
• • Ages 18 years or older (no upper limit) for bone marrow or skin tissue sampling.
• EXCLUSION CRITERIA:
• • Unable to comprehend the investigational nature of the protocol participation.
• • CBC determined outside expected normal ranges for the subject (bone marrow and skin tissue donors only).
• • Pregnancy
• • Age less than 18 years for skin tissue sampling, bone marrow aspirate and biopsy.
• • Off campus volunteers for skin tissue sampling bone marrow aspirate and biopsy.