rhTSH-Thyroid Ablation With 1850 MBq of 131I
Launched by UNIVERSITY OF SIENA · Mar 28, 2007
Trial Information
Current as of August 11, 2025
Completed
Keywords
ClinConnect Summary
Aim: Recently, a multicenter study in differentiated thyroid cancer (DTC) patients showed that 3700 MBq of 131I after rhTSH stimulation had successful post-surgical thyroid ablation rate similar to that obtained after thyroid hormone withdrawal. We investigated whether 1850 MBq of 131I have a rate of successful ablation similar to 3700 MBq in patients prepared with rhTSH.
Methods: Seventy-two patients with DTC were randomly assigned after surgery to receive 1850 MBq (group A, n: 36) or 3700 MBq (group B, n: 36) of 131I after rhTSH. The two groups were comparable for age, sex, histotype and...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Newly diagnosed differentiated thyroid cancer patients, more than 18 years old, recently treated by near total thyroidectomy were eligible for the study
- Exclusion Criteria:
- • Evidence of distant metastases and/or significant local invasion
About University Of Siena
The University of Siena, a leading academic institution in Italy, is dedicated to advancing medical research and improving patient care through innovative clinical trials. With a strong emphasis on interdisciplinary collaboration, the university leverages its extensive expertise in various fields of healthcare to design and conduct rigorous studies that address critical medical questions. Committed to ethical standards and patient safety, the University of Siena aims to translate scientific findings into practical applications, ultimately enhancing treatment options and health outcomes for diverse populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Siena, , Italy
Patients applied
Trial Officials
Furio Pacini, MD
Principal Investigator
Section of Endocrinology, University of Siena
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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