Effect of Clopidogrel Loading and Risk of PCI

Launched by UNIVERSITY HEART CENTER FREIBURG - BAD KROZINGEN · Apr 5, 2007

Keywords

ClinConnect Summary

Background: Platelet responses after loading with clopidogrel are highly variable. The impact of this variability on the peri-interventional risk of patients undergoing PCI has not been investigated prospectively.

Objectives: Our prospective study test the hypothesis that the 30-day clinical outcome of elective percutaneous catheter intervention (PCI) differs between strata defined by quartiles of platelet aggregation after loading with 600mg of clopidogrel. Further on we will investigate impact of the variability in platelet response on long-term outcome after PCI.

Methods: Our study wil...

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Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing elective coronary stenting
• • Pretreatment with a bolus dose of 600mg of clopidogrel prior to coronary stent implantation
• • Pretreatment with aspirin ≥ 100 mg per day for at least 7 days
• • Age \> 18 years
• • Written consent
• Exclusion Criteria:
• • Troponin T on admission \> 0.03 ng/mL
• • Myocardial infarction or fibrinolytic therapy within the previous 14 days
• • Cardiogenic shock
• • Contraindication for aspirin or clopidogrel
• • Oral anticoagulation
• • Pretreatment with heparin or a thienopyridine within the previous 14 days
• • Use of a GP IIb/IIIa-receptor antagonist during PCI
• • Platelet count \< 100.000/µl
• • Severe disorders of the coagulation system
• • Severe impairment of liver or kidney function
• • Cancer