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Search / Trial NCT00471146

Study Of Gemcitabine Plus AG-013736 Versus Gemcitabine For Advanced Pancreatic Cancer.

Launched by PFIZER · May 7, 2007

Trial Information

Current as of July 21, 2025

Completed

Keywords

Randomized Study Of Gemcitabine Plus Ag 013736 Versus Gemcitabine Plus Placebo For Advanced Pancreatic Cancer.

ClinConnect Summary

This study was prematurely discontinued for futility on 23 January 2009, based on a planned interim analysis by an independent Data Safety Monitoring Board (DSMB) that found no evidence of improvement in the primary endpoint (survival) in patients treated with axitinib and gemcitabine compared to gemcitabine alone. Enrollment on this study has been discontinued.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Histologically or cytologically confirmed, metastatic or locally-, advanced pancreatic adenocarcinoma not amenable to curative resection.
  • Adequate renal, hepatic and bone marrow function.
  • Performance status 0 or 1.
  • Exclusion Criteria:
  • Prior treatment with any systemic chemotherapy for metastatic disease.
  • Prior treatment with gemcitabine, AG-013736, or other vascular endothelial growth factor inhibitors.
  • Current or recent bleeding, thromboembolic event and or use of a thrombolytic agent.
  • Inability to take oral medication.

About Pfizer

Pfizer Inc. is a global leader in biopharmaceutical innovation, dedicated to discovering, developing, and delivering advanced therapies that enhance patient outcomes across a wide range of medical conditions. With a rich history of scientific research and a commitment to quality, Pfizer focuses on areas such as oncology, immunology, cardiology, and rare diseases. The company leverages cutting-edge technology and collaborates with healthcare professionals, regulatory bodies, and academic institutions to conduct rigorous clinical trials that ensure the safety and efficacy of its products. Pfizer's mission is to bring breakthroughs that change patients' lives, exemplifying its commitment to health and wellness worldwide.

Locations

Pasadena, California, United States

Pomona, California, United States

Rancho Cucamonga, California, United States

West Covina, California, United States

Mineola, New York, United States

Montreal, Quebec, Canada

Federal Way, Washington, United States

Lakewood, Washington, United States

Tacoma, Washington, United States

La Jolla, California, United States

Syracuse, New York, United States

Knoxville, Tennessee, United States

St. Louis, Missouri, United States

Puyallup, Washington, United States

Bruxelles, , Belgium

Leuven, , Belgium

Wilrijk, , Belgium

Chicago, Illinois, United States

Berlin, , Germany

Observatory, , South Africa

Lund, , Sweden

Northwood, Middlesex, United Kingdom

Manchester, , United Kingdom

Moscow, , Russian Federation

Memphis, Tennessee, United States

Tampa, Florida, United States

Louisville, Kentucky, United States

Salt Lake City, Utah, United States

Edmonton, Alberta, Canada

Paris Cedex 13, , France

Austin, Texas, United States

Port Elizabeth, , South Africa

Barcelona, , Spain

Billings, Montana, United States

Kelowna, British Columbia, Canada

Toronto, Ontario, Canada

Montreal, Quebec, Canada

Milano, , Italy

Uppsala, , Sweden

East Bentleigh, Victoria, Australia

Brussel, , Belgium

Paris, , France

Dresden, , Germany

London, , United Kingdom

Alton, Illinois, United States

Southaven, Mississippi, United States

Santa Fe, , Argentina

Bologna, , Italy

Singapore, , Singapore

Malaga, , Spain

Augusta, Georgia, United States

San Diego, California, United States

Columbus, Mississippi, United States

Corinth, Mississippi, United States

Tupelo, Mississippi, United States

St. Leonards, New South Wales, Australia

Ulm, , Germany

Pamplona, Navarra, Spain

Sylvania, Ohio, United States

Gent, , Belgium

Taichung, , Taiwan

Rancho Mirage, California, United States

Atlanta, Georgia, United States

Lincoln, Nebraska, United States

Edinburgh, , United Kingdom

Birmingham, , United Kingdom

Winnipeg, Manitoba, Canada

Muenchen, , Germany

Budapest, , Hungary

Seoul, , Korea, Republic Of

Taipei, , Taiwan

Lynchburg, Virginia, United States

Madrid, , Spain

Hollywood, Florida, United States

Annapolis, Maryland, United States

Burlington, Massachusetts, United States

Clayton, Victoria, Australia

Oshawa, Ontario, Canada

Jeffersonville, Indiana, United States

Shelbyville, Kentucky, United States

Victoria, British Columbia, Canada

Dublin 24, , Ireland

Padova, , Italy

Whitchurch, Cardiff, United Kingdom

Catania, , Italy

Kingston, Ontario, Canada

Las Vegas, Nevada, United States

Pembroke Pines, Florida, United States

Shatin, , Hong Kong

Yokohama Shi, Kanagawa, Japan

Cape Town, , South Africa

Nagoya, Aichi, Japan

Chuo Ku, Tokyo, Japan

Oldenburg, , Germany

Wels, , Austria

Everett, Washington, United States

Wollongong, New South Wales, Australia

Pretoria, , South Africa

Zalaegerszeg, , Hungary

Parktown, , South Africa

Salzburg, , Austria

Suntougun, Shizuoka, Japan

Indianapolis, Indiana, United States

Dublin, , Ireland

Fukuoka Shi, Fukuoka Ken, Japan

Glendora, California, United States

Clichy Cedex, , France

Kalamazoo, Michigan, United States

Canton, Ohio, United States

Portland, Oregon, United States

Kennewick, Washington, United States

Moncton, New Brunswick, Canada

St Herblain Cedex, , France

Santa Cruz De Tenerife, , Spain

Mannheim, , Germany

Antioch, California, United States

San Leandro, California, United States

Berlin, , Germany

Essen, , Germany

Magdeburg, , Germany

Beech Grove, Indiana, United States

Ahmedabad, Gujarat, India

Round Rock, Texas, United States

Bangalore, Karnataka, India

Sandton, , South Africa

Peabody, Massachusetts, United States

Redlands, California, United States

Baton Rouge, Louisiana, United States

Szentes, , Hungary

Kaposvar, , Hungary

Toledo, , Spain

Maidstone, Kent, United Kingdom

St. Petersburg, , Russian Federation

Palma De Mallorca, Islas Baleares, Spain

Mostoles, Madrid, Spain

Stuart, Florida, United States

Pretoria, Gauteng, South Africa

Cape Town, Western Cape, South Africa

Madrid, , Spain

Leicester, Leicestershire, United Kingdom

Edinburgh, Scotland, United Kingdom

Manchester, , United Kingdom

Corona, California, United States

Laverne, California, United States

Pamona, California, United States

Pleasent Hill, California, United States

Coeur D'alene, Idaho, United States

Dallas, Texas, United States

Bahia Blanca, Buenos Aires, Argentina

La Plata, Buenos Aires, Argentina

Ciudad Autonoma De Buenos Aires, , Argentina

Wien, , Austria

La Chaussee Saint Victor, , France

Marseille, , France

Montpellier Cedex 02, , France

Pessac Cedex, , France

Rouen, , France

Greifswald, , Germany

Shatin, Nt, Hong Kong

Cochin, Kerala, India

Andhra, Pradesh, India

Chennai, Tamil Nadu, India

Verona, , Italy

Chiba Shi, Chiba Ken, Japan

Chiba City, Chiba, Japan

Kashiwa Shi, Chiba, Japan

Osaka Shi, Osaka Fu, Japan

Amsterdam, Noord Holland, Netherlands

Omsk, , Russian Federation

Sochi, , Russian Federation

Las Palmas De Gran Canaria, , Spain

Winterthur, , Switzerland

Kuei Shan Jsoamg, Taoyuan County, Taiwan

Withington, Manchester, United Kingdom

Birmingham, , United Kingdom

Southhampton, , United Kingdom

Patients applied

0 patients applied

Trial Officials

Pfizer CT.gov Call Center

Study Director

Pfizer

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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