A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes

Launched by M.D. ANDERSON CANCER CENTER · Jun 27, 2007

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how a person's energy levels and fitness before major cancer surgery may affect their recovery afterward. The researchers want to see if measuring how well the body exchanges gases (like oxygen and carbon dioxide) during surgery can help predict complications that might arise after the operation. This study specifically looks at patients diagnosed with abdominal or pelvic cancers, such as esophageal or lung cancer, who are preparing for surgery after treatments like chemotherapy or radiation.

To participate in the trial, you need to be at least 18 years old and have been cleared for surgery by medical professionals at the Perioperative Evaluation and Management Center. You should be able to exercise to some extent, as those who are bedridden or unable to move around won't qualify. If you join the study, you’ll undergo a series of evaluations to assess your fitness and health status before the surgery. It's important to know that this study is looking for individuals who are currently not pregnant and do not have certain recent health issues, like heart problems or strokes. Overall, this trial aims to improve how doctors assess risks for patients undergoing major surgeries, ultimately helping to enhance patient care and recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants 18 years of age or older.
• • Participants with newly diagnosed esophageal and lung cancer undergoing neoadjuvant chemotherapy, radiation therapy, and/or immunotherapy.
• • Participants who have signed the consent form to participate in the study.
• • Participants must have been evaluated in the Perioperative Evaluation and Management (POEM) Center or by a staff Anesthesiologist.
• • All laboratory and diagnostic evaluations required or used to evaluate the patient must be completed. All participants must be approved to undergo anesthesia by the standards of the POEM Center.
• • No samples belonging to vulnerable populations (children, pregnant women, cognitively impaired adults or prisoners) will be allowed from participation.
• Exclusion Criteria:
• • Participant is under age 18.
• • Participant is unwilling to sign consent.
• • Participant is unable to exercise (bedridden or wheel chair bound).
• • Participant is enrolled in another study deemed by the investigator to affect oxygen metabolic efficiency and not presently the standard of care at MDACC.
• • Participant's condition is deemed unsatisfactory for surgery after the preanesthetic evaluation.
• • Participant has had a myocardial infarction within three months of the preanesthetic evaluation or presents with new or unstable angina.
• • Participant has a history of a cerebrovascular accident or transit ischemic attacks within three months of the preanesthetic evaluation.
• • Participant has a history of a pulmonary embolic event within three months of the preanesthetic evaluation.
• • Participant is known to have acute or chronic deep vein thrombosis.
• • Participant is pregnant.