Lipoarabinomannan (LAM) Enzyme-Linked Immunosorbent Assay (ELISA) in Diagnostics of Childhood Tuberculosis (TB)
Launched by UNIVERSITY HOSPITAL, BONN · Aug 6, 2007
Trial Information
Current as of August 02, 2025
Unknown status
Keywords
ClinConnect Summary
Among candidate new diagnostics for TB, a test for mycobacterial Lipoarabinomannan (LAM) excretion in urine has shown promising results in one Tanzanian study: The sensitivity for detecting TB culture-positive patients was 80.3%. Of 103 healthy volunteers, only one gave a false positive result (Boehme, 2005).
Until now, there are only data concerning this test for diagnosis of adult disease. For evaluation of routine use in children in countries like Malawi, we are starting a prospective study. Children 0-14 years of age with suspected TB will be investigated using TB culture as the gold s...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • age 0-14 years
- • suspicion of active TB or TB contact
- Exclusion Criteria:
- • no informed consent
About University Hospital, Bonn
The University Hospital Bonn is a leading academic medical center dedicated to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the institution leverages its extensive expertise in various medical disciplines to investigate novel therapies and enhance patient outcomes. With a commitment to ethical standards, patient safety, and rigorous scientific methodologies, the University Hospital Bonn collaborates with multidisciplinary teams and partners to drive forward-thinking solutions in medicine, ultimately contributing to the global body of clinical knowledge.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Kapiri/Mchinji, Mchinji, Malawi
Patients applied
Trial Officials
Norbert Heinrich, MD
Study Chair
University of Bonn
John Chimphamba, Clinical Officer
Principal Investigator
Our Lady of Mount Carmel Hospital, Kapiri
Andreas Mueller, PD Dr med.
Study Chair
University of Bonn
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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