The Long-term Evaluation of Glucosamine Sulphate Study
Launched by UNIVERSITY OF SYDNEY · Aug 7, 2007
Trial Information
Current as of May 21, 2025
Unknown status
Keywords
ClinConnect Summary
The LEGS study is a double blind, placebo-controlled randomised clinical trial using a 2 x 2 factorial design. Participant will be randomly allocated to one of the four possible treatment combinations:
* Glucosamine and Chondroitin (double active)
* Placebo Glucosamine and Chondroitin
* Glucosamine and Placebo Chondroitin
* Placebo Glucosamine and Placebo Chondroitin (double placebo)
Each allocation involves taking 4 study treatment capsules once a day for two years.
A total of 600 participants with symptomatic knee OA will be recruited by general media advertising and by General Practit...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Knee pain, or taking NSAIDs/ analgesia for knee pain on most days past month
- • Knee pain 4-10 on 10cm VAS
- • Medial tibio-femoral compartment joint space narrowing in symptomatic knee
- Exclusion Criteria:
- • Unstable diabetes
- • \<2mm medial tibio-femoral compartment joint space width
About University Of Sydney
The University of Sydney is a leading research institution in Australia, renowned for its commitment to advancing medical science and improving healthcare outcomes through innovative clinical trials. With a robust infrastructure and a multidisciplinary team of experts, the university fosters a collaborative environment that integrates cutting-edge research with clinical practice. The institution emphasizes ethical standards, patient safety, and scientific rigor in its trials, aiming to translate findings into real-world applications that benefit diverse populations. Through its dedication to excellence and impact, the University of Sydney continues to contribute significantly to the fields of medicine and public health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Sydney, New South Wales, Australia
Patients applied
Trial Officials
Marlene Fransen, PhD, MPH
Principal Investigator
University of Sydney, Faculty of Health Sciences
Richard Day, MB, BS, MD
Principal Investigator
University of New South Wales
Charles Bridges-Webb, MB, BS
Principal Investigator
Royal College of General Practitioners
John Edmonds, MB,BS
Principal Investigator
University of New South Wales
Robyn Norton, PhD, MPH
Principal Investigator
The George Institute, University of Sydney
Mark Woodward, PhD, MSc
Principal Investigator
The George Institute, University of Sydney
Lynette March, PhD, MB, BS
Principal Investigator
University of Sydney
Philip Sambrook, MB, BS
Principal Investigator
Institute of Bone and Joint Research, University of Sydney
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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