Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders

Launched by MEMORIAL SLOAN KETTERING CANCER CENTER · Dec 21, 2007

Keywords

ClinConnect Summary

This clinical trial is focused on understanding the genetic factors that contribute to certain blood cancers, specifically Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, and leukemia. The researchers aim to gather information from individuals who either have these conditions themselves or have family members affected by them. By studying the genetics of these families, the trial hopes to uncover patterns that could help identify the causes of these diseases and improve treatment options in the future.

If you or a family member have been diagnosed with any of these types of cancer, or if you have a family history of them, you might be eligible to participate. The study welcomes all ages and genders, and also includes family members of patients, such as siblings, parents, and grandparents. Participants will help by providing their health information and possibly giving DNA samples, which will be used to better understand how these cancers run in families. It's important to note that this study is designed to be low-risk, especially for children, and parental consent will be required for minors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals with a personal and/or family history of lymphoma or lymphoproliferative disease B-cell malignancies, or multiple myeloma referred for study participation, or MSK patients referred from to the MSKCC outpatient clinics of the Lymphoma, Multiple Myeloma, or Leukemia Services in the Department of Medicine in consultation for treatment who are found on routine history or through a Family History Questionnaire (FHQ) (Appendix A). Individuals who have relatives or members of successive generations of the family affected with Hodgkin's disease, non-Hodgkin's lymphoma, lymphoid leukemia, multiple myeloma other lymphoproliferative disease prostate or pancreatic cancers, or other conditions suggesting hereditary cancer at the discretion of the MSKCC Principal Investigator. Patients with lymphoma, associated with colon and renal cancer will be eligible for DNA storage through this protocol. Family members or probands with Hodgkin's disease who are women who received therapeutic irradiation for Hodgkin's disease" or who developed secondary cancers after Hodgkin's disease are also eligible for participation.
• • The criteria for eligibility are broad because the ascertainment by the computerized FHQ does not allow for resolution of different types of lymphoma or different types of leukemia. Patient recall of this information is also imprecise. More accurate family history information will be obtained upon contact of family members and diagnoses will be verified by obtaining pathologic documentation. The spectrum of familial lymphoproliferative syndromes (LPS) may include all types of lymphoma as well as chronic lymphocytic leukemia. This is an additional reason to have a broad eligibility. Subset analysis will be performed on specific types of lymphoid neoplasms. DNA of patients with a family history of lymphoma who have consented to protocol 93-102 ("Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers") will also be eligible for inclusion in this study.
• • Family members of probands including patients, sisters, brothers, halfbrothers and sisters, sons, daughters, grandparents, as well as aunts and uncles are also eligible. An effort will be made to ascertain all living affected and unaffected living relatives in the affected lineage. An emphasis will be on affected sibling pairs and both parents, if alive.
• • As this study involves research that presents no greater than minimal risk to children (see Sec. 46.404 of Federal Regulations part 46), minors are also eligible for participation. The assent of any minor should be obtained before the patient is enrolled into this study, as well as the consent of the legal guardian.
• Exclusion Criteria:
• • N/A