Barrett's Esophagus Related Neoplasia (BERN) Project

Launched by MIDWEST BIOMEDICAL RESEARCH FOUNDATION · Jan 9, 2008

Keywords

ClinConnect Summary

The Barrett's Esophagus Related Neoplasia (BERN) Project is a clinical trial that aims to improve how doctors detect and treat early changes in the esophagus that could lead to cancer. The trial is focusing on using advanced techniques, like high-resolution endoscopy and special imaging tools, to find Barrett's esophagus and early signs of cancer more effectively. Researchers are also creating a video guide to help train doctors on identifying different types of lesions (abnormal tissue) and are working on a system to classify these findings. They will also monitor the safety and outcomes of a procedure called endoscopic mucosal resection (EMR), which helps remove abnormal tissue.

To participate in this trial, individuals must be between 18 and 80 years old and able to provide written consent. They should be referred for an endoscopy, either for screening or treatment of early-stage Barrett's esophagus. Participants can expect to undergo endoscopic procedures and help advance research that could improve detection and treatment methods for others in the future. Currently, the trial is actively recruiting participants at the Kansas City VA medical center, and the study is open to all genders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-80 years
• • Patients must be able to provide written informed consent
• • Patients referred for endoscopy for screening/surveillance of BE or for endoscopic treatment of BE with early mucosal neoplasia
• Exclusion Criteria:
• • Current use of aspirin, non-steroidal anti-inflammatory agents(NSAIDs),or chronic anticoagulants that cannot be discontinued prior to the procedure.
• • Inability to provide written informed consent
• • Significant thrombocytopenia or coagulopathy
• • Any significant co-morbid condition that would prevent the safe administration of conscious sedation