Effect of Nephral 400 ST Dialysis Membrane on Coagulation in Hemodialysis

Launched by ULLEVAAL UNIVERSITY HOSPITAL · Jan 14, 2008

Keywords

ClinConnect Summary

Six consecutive hemodialysis (HD) sessions are evaluated per patient, altogether 10 - 12 stable HD patients (or at least 48 HD sessions altogether). During these six sessions, AN69ST and Fx8 are used on alternate days. Dalteparin is given intravenously as a single bolus dose at start of HD (50% of the conventional dose). Clinical clotting is evaluated visually each hour of HD after blood draining of the venous air trap: 1=no clot, 2=a fibrinous ring, 3=a clot \<1 cm, 4=a clot \>1 cm and 5=coagulated system (stop in HD).

Blood specimens are taken at start and after each hour of HD. Markers ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patient aged 18 years or more having been in chronic HD for at least 1 month
• • dialysis time at least 4 hours 3 times per week
• • blood flow at least 200 ml/min
• • Fragmin dose unchanged the last week before study start
• • Fragmin given intravenously as one single dose at HD start
• • Haemoglobin \>= 11.0 g/dL and stable +/- 20% the last week before study start
• • erythropoietin and iron dose unchanged the last week before study start
• • written and orally informed consent given by the patient
• Exclusion Criteria:
• • treatment with acetylsalicylic acid (ASA)
• • use of Warfarin or another oral anticoagulant
• • clinical signs of infection
• • disseminated malignant disease