Nifedipine Compared to Atosiban for Treating Preterm Labor

Launched by RAED SALIM · Jan 13, 2008

Keywords

ClinConnect Summary

No description provided

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Gestational age between 24 to 34 weeks which had been documented by a definite LMP and sonography up to 20 weeks.
• 2. All women fulfilled the criteria of preterm labor. The diagnosis of preterm labor required the presence of 4 uterine contractions or more over 30 minutes, each lasting at least 30 seconds, and documented cervical change. The cervical criteria were met when either of the following was present:
• • 1. Nulliparous women: a single cervical examination demonstrating dilatation of 0 cm to 4 cm and effacement of at least 50%
• • 2. Multiparous women: a single cervical examination demonstrating dilatation of 1 cm to 4 cm and effacement of at least 50%.
• • 3. Provision of written informed consent
• Exclusion Criteria:
• • 1. Chorioamnionitis
• • 2. Preterm rupture of membranes
• • 3. Vaginal bleeding
• • 4. Major fetal malformations
• • 5. Severe hypertensive disorders
• • 6. Intrauterine growth restriction (\< 5th percentile).
• • 7. Non-reassuring fetal heart rate
• • 8. Maternal contraindications
• • 1. Chronic hypertension
• • 2. Systolic blood pressure \< 90 mmHg
• • 3. Cardiovascular disease
• • 4. Elevated hepatic enzymes
• • 9. Congenital or acquired uterine malformation