Clinical Applications of High-Frequency Oscillations

Launched by CHILDREN'S HOSPITAL MEDICAL CENTER, CINCINNATI · Jan 24, 2008

Keywords

ClinConnect Summary

The purpose of this study is to go beyond conventional analyses of brain signals in narrow frequency bands (typically 1-30 Hz) by measuring brain signals from infraslow to very fast frequencies (0.01 - 2800 Hz). Specifically, we propose to study physiological high-frequency oscillations (HFOs) in sensorimotor, auditory, visual, and language-evoked magnetic fields, and to investigate pathological HFOs in epilepsy, migraines, and other disorders. This is clinically important for several reasons.

For instance, there are 400,000 to 600,000 patients with refractory epilepsy in the United States...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy and cooperative.
• • Ages: from 1 day to 69 years (male or female).
• • Normal hearing and vision.
• • Normal hand movement.
• • No history of neurological or psychiatric diseases.
• • No family history of genetic neurological or psychiatric diseases.
• • No metal implants such as pacemakers, neuro-stimulators, cochlear implants, etc.
• Exclusion Criteria:
• • Taking any medications for depression, neurologic, or psychiatric conditions.
• • Not feeling well, having epilepsy, or other brain disorders.
• • Recent concussion or head injury.
• • Presence of metal in the body, such as dental braces, which could cause "magnetic noise". A simple, quick "magnetic noise screening" can be conducted at the MEG Center to determine eligibility.
• • Presence of electrical or metal implants such as pacemakers, neuro-stimulators, or orthopedic pins or plates. The research nurse will discuss all exclusions in further detail before the magnetic resonance imaging (MRI) scan.
• • Inability to pass the pre-experimental screening.