Echo Assessment of Intraventricular Dyssynchrony

Launched by ITALIAN SOCIETY OF CARDIOLOGY · Mar 27, 2008

Keywords

ClinConnect Summary

The IMPROVE study has 3 main purposes:

1. definition of reference values of echocardiographic mechanical dyssynchrony (DYS) indexes in a population of healthy subjects;
2. definition of the feasibility and reproducibility of such indexes in healthy subjects and in HF patients undergoing implantation of a biventricular pacemaker;
3. definition of the accuracy of such indexes for predicting response to CRT.

STUDY DESIGN. Multicenter, prospective, observational study that will be carried out in 6 Italian sites of acknowledged expertise in LV DYS evaluation and biventricular pacemaker impl...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \> 18 years.
• • Sinus rhythm.
• • Chronic heart failure (\>6 weeks duration) refractory to maximized drug therapy.
• • NYHA class III-IV.
• • LV ejection fraction less than 35% by RT3DE.
• • Indexed LV end-diastolic diameter \>3.2 cm/m2 by 2D echocardiography and/or indexed end-diastolic volume \>75 ml/m2 by 3D echocardiography.
• Exclusion Criteria:
• • Hypertrophic, restrictive, obstructive cardiomyopathy.
• • Primitive and hemodynamically significant valve disease (defined as valvular stenosis greater than mild, and 3+ or 4+/4+ valvular regurgitations).
• • Constrictive pericarditis.
• • Primitive pulmonary hypertension.
• • Uncorrected congential heart disease.
• • Patients candidate to heart surgery.
• • Patients with acute myocardial infarction, severe unstable angina and stroke that occurred within 6 weeks prior the study enrollment.
• • Patients with life expectation \<1 year due to disease unrelated to the heart failure.
• • Pregnant women.
• • Refusal to give the informed consent.