The Natural History of Small Airways Physiology in Diseased and Healthy States

Launched by IMPERIAL COLLEGE LONDON · May 13, 2008

Keywords

ClinConnect Summary

Background

The main objective of this study is to measure the damage of the small airways in lung disease exploring the "silent zone" with methods that have not been used before together in the same patients. Furthermore, because this is a 4 year longitudinal study, the study team will investigate the time related changes of small airway function in lung disease and normal healthy subjects.

The study will also investigate the relationship between small airway resistance and inflammation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • male or female, aged between 18-85 years;
• • volunteers who are able to give written informed consent Patients meeting the diagnostic criteria for asthma, COPD, ILD, CF, chronic cough.
• Exclusion Criteria:
• • upper respiratory tract infection within the previous 28 days
• • any history or evidence of renal, cardiovascular, gastrointestinal or hepatic disease
• • any history and evidence of neuropsychiatric disease
• • treatment with antibiotics within 4 weeks prior to the study
• • alcohol, drug abuse or any other condition associated with poor compliance
• • breast feeding
• • pregnancy
• • are unable to provide written informed consent