Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants

Launched by MEDICAL COLLEGE OF WISCONSIN · Jul 3, 2008

Keywords

ClinConnect Summary

**Clinical Trial Summary: Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants**

This clinical trial is looking at how certain genetic differences in premature infants might make them more likely to develop chronic lung disease (CLD) and other health issues such as necrotizing enterocolitis (NEC), sepsis, patent ductus arteriosus (PDA), and intraventricular hemorrhage (IVH). Researchers want to find out if specific genes that are important for the development of vital organs play a role in these conditions. They are also exploring whether measuring certain substances in the blood can help identify which infants are more likely to experience these complications.

To participate in this study, infants must weigh less than 1500 grams (about 3.3 pounds) at birth. Unfortunately, infants with congenital heart disease (other than PDA) or significant birth defects affecting the gastrointestinal, respiratory, or kidney systems cannot join. If your child is eligible and participates, they will undergo genetic testing and blood tests, with the hope that this research will improve understanding and treatment of health issues in premature infants. The study is currently recruiting participants, and all infants, regardless of gender, are welcome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Infants born weighing less than 1500 grams
• Exclusion Criteria:
• • Infants born with congenital heart disease (other than patent ductus arteriosus)
• • major congenital anomalies of the GI tract, respiratory tract, or kidneys