Inflammatory Response After Muscle and Skeleton Trauma
Launched by UNIVERSITY OF ULM · Jul 2, 2008
Trial Information
Current as of August 11, 2025
Completed
Keywords
ClinConnect Summary
Polytraumatized patients are via a systemic inflammatory response syndrome at high risk for an uneventful outcome in the posttraumatic phase. One of the main functions of the inflammatory response is the recognition and elimination of damaged tissues and microorganisms. In polytraumatized patients, a huge amount of damaged cells occurs which has to be eliminated by programmed cell death (apoptosis)without damaging surrounding tissues. It remains unclear whether, when and how an interplay of complement system, NF-kB, danger and pattern recognition receptors, apoptosis, mesenchymal stem cells...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • multiple trauma injury, injury severity score (ISS) \> 18 with
- • 1. isolated fractures of the extremities
- • 2. fractures of the extremities combined with blunt/penetrating visceral trauma
- • 3. fractures of the extremities combined with blunt/penetrating thoracic trauma
- • 4. isolated head injury with morphological changes in CCT
- • 5. combination of points 1 - 4
- Exclusion Criteria:
- • life expectancy \< 24 hours
- • participation in other trials
- • ISS \< 18
- • cardiopulmonary reanimation on the accident scene or dying immediately after hospital admission
- • age \< 18 years
- • known or suspected pregnancy
- • patients with ray-treatment or chemotherapy within the last three months
About University Of Ulm
The University of Ulm is a leading academic institution located in Germany, renowned for its commitment to cutting-edge research and innovation in the fields of medicine and health sciences. As a clinical trial sponsor, the university leverages its robust network of researchers and clinical experts to advance medical knowledge and improve patient outcomes. With a focus on interdisciplinary collaboration, the University of Ulm conducts comprehensive clinical studies that adhere to the highest ethical standards and regulatory guidelines. Through its research initiatives, the university aims to contribute significantly to the development of new therapies and treatment modalities, fostering a deeper understanding of various health conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ulm, , Germany
Patients applied
Trial Officials
Manfred M Weiss, MD, MBA
Principal Investigator
Clinic of Anesthesiology, University Hospital Medical School, Steinhoevelstrasse 9, 89070 Ulm, Germany
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials