Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

Launched by UCONN HEALTH · Sep 29, 2008

Keywords

ClinConnect Summary

This clinical trial is studying how two specific proteins in the blood behave during episodes of acute heart failure, a condition where the heart struggles to pump blood effectively. The researchers want to find out if these proteins increase when a person experiences heart failure symptoms, which can include shortness of breath, swelling, and an overall feeling of tiredness. By understanding the relationship between these proteins and heart failure, the study aims to improve our knowledge about heart conditions and potentially help in their diagnosis.

To participate in this trial, individuals must be over 18 years old and have either stable or worsening heart failure symptoms. This includes people who show signs of heart failure through imaging tests or have symptoms like difficulty breathing or swelling. Healthy individuals without a history of heart problems will also be recruited to serve as a comparison group. Participants can expect to provide blood samples for testing, and the study is currently looking for volunteers. Importantly, anyone unable to give informed consent or who has had recent surgery will not be eligible to join the study. Overall, this research could offer valuable insights into heart health and the challenges faced by those with heart failure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals aged \>18yrs
• • stable or decompensated heart failure, irrespective of LVEF
• • decompensated heart failure clinical symptoms such as dyspnea, rales, edema, elevated jugular venous pressure, or ascites
• • Imaging evidence of heart failure (cardiomegaly, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures)
• • Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls.
• Exclusion Criteria:
• • Subjects who are unable to give informed consent
• • Subjects who had undergone cardiac or non-cardiac surgery in the 3 months before enrollment
• • Pregnant subjects are not excluded