WOEST ( What is the Optimal antiplatElet & Anticoagulant Therapy in Patients With Oral Anticoagulation and Coronary StenTing)

Launched by R&D CARDIOLOGIE · Oct 8, 2008

Keywords

ClinConnect Summary

Chronic oral antithrombotic treatment is necessary in patients with mechanical heart valves and in the majority of patients with atrial fibrillation. When these patients have to undergo Percutaneous Coronary Intervention (PCI) with stenting, there is also an indication for treatment with aspirin and clopidogrel. However, triple therapy is known to augment the risk for bleeding complications.Unfortunately, no prospective data are available to solve this issue. Nevertheless, it all comes down to finding the ideal therapy in patients with both atrial fibrillation and percutaneous intervention ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients is on oral anticoagulation therapy and this will be continued throughout the period of 1 year-and deployment of at least 1 coronary stent (bare metal stent (BMS) or drug eluting stent (DES)). -age of more than 18 years
• Exclusion Criteria:
• • cardiogenic shock,
• • contra-indication for aspirin or clopidogrel
• • allergy to aspirin or clopidogrel,
• • documented peptic ulcer disease within the previous six months,
• • pregnancy and
• • previous intracerebral haemorrhage or
• • significant thrombocytopenia (platelet count \< 50x10 9/L).
• • major bleeding according to timi criteria within the past 12 months
• • age \> 80 years