Predicting Bleeding Risk on Anticoagulant Therapy for Venous Thromboembolism

Launched by OTTAWA HOSPITAL RESEARCH INSTITUTE · Nov 10, 2008

Keywords

ClinConnect Summary

Oral anticoagulant therapy for patients who are at risk of developing blood clotting problems is used by between 400,000-600,000 Canadians annually. The use of this drug represents the most common cause of patient adverse medical outcomes due to medical errors. Furthermore, many patients have adverse outcomes using these drugs because physicians are not able to predict which patients are likely to have bleeding outcomes. Much effort has gone into developing ways to predict which patients are at risk of clotting but almost no work has gone into ways of predicting which patients would be at h...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • \>=18 years old
• • provoked or unprovoked venous thromboembolism
• • objectively confirmed venous thromboembolism
• • treated with an oral anticoagulant(vitamin K antagonist or new oral anticoagulant) for at least 3 months with plans to continue long-term
• • if taking a vitamin K antagonist; INR target is between 2.0-3.0
• • if taking a vitamin K antagonist; must have taken it for the last 3 consecutive weeks (minimum)
• Exclusion Criteria:
• • major bleeding while taking oral anticoagulants
• • active bleeding at study enrollment
• • active cancer - current or at the time of VTE diagnosis
• • unable to provide written informed consent
• • refusal to provide written informed consent