Escitalopram (Lexapro) for the Treatment of Postpartum Depression
Launched by MASSACHUSETTS GENERAL HOSPITAL · Jan 30, 2009
Trial Information
Current as of July 21, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Women ages 18 to 45 years old
- • Subjects must meet criteria for a major depressive episode with symptoms developing within three month of live childbirth
- • Subjects must present within six months of childbirth
- • MADRS score \>15
- • BAI score \>10
- • Subjects will be able to be treated on an outpatient basis
- • Subjects will be able to provide written informed consent
- Exclusion Criteria:
- • Subjects who have taken any psychotropic medication, including antidepressants and anti-anxiety medication, within the past two weeks (with the exception of non-benzodiazepine medications used for sleep, including trazodone, zolpidem, eszopiclone, etc)
- • Suicidal ideation with active plan or intent, as determined by the investigator
- • Presence of psychotic symptoms or homicidal ideation
- • History of mania or hypomania
- • Pregnant or breastfeeding
- • Presence of chronic depression or dysthymia, or chronic or treatment resistant anxiety disorders, as determined by investigator
- • Active alcohol/substance abuse currently or within the past year
- • Abnormal TSH, severe anemia, or uncontrolled hypertension
About Massachusetts General Hospital
Massachusetts General Hospital (MGH) is a leading academic medical center located in Boston, Massachusetts, renowned for its commitment to advancing medical research and patient care. As a prominent teaching hospital affiliated with Harvard Medical School, MGH plays a pivotal role in clinical trials across a wide range of disciplines, including cardiology, oncology, neurology, and more. The institution is dedicated to fostering innovative research that translates into effective therapies and improved health outcomes. MGH's Clinical Trials Office provides comprehensive support to facilitate the design, implementation, and management of clinical studies, ensuring adherence to the highest ethical standards and regulatory compliance. With a focus on collaboration and patient-centered care, MGH strives to enhance medical knowledge and contribute to the future of healthcare.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Boston, Massachusetts, United States
Patients applied
Trial Officials
Marlene P Freeman, MD
Principal Investigator
Massachusetts General Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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