Genetics of Type 2 Diabetes in West Africans

Launched by NATIONAL HUMAN GENOME RESEARCH INSTITUTE (NHGRI) · Feb 4, 2009

Keywords

ClinConnect Summary

This clinical trial is studying the genetics of type 2 diabetes (T2D) in West Africans, specifically among the Yoruba people in Ibadan, Nigeria. The goal is to identify genetic factors that may make individuals more susceptible to diabetes and its complications. By understanding these genetic links, researchers hope to find better ways to prevent and treat diabetes not only in West Africa but also in other populations, including African Americans.

To participate in this study, individuals must be at least 18 years old and have been diagnosed with type 2 diabetes, or be newly diagnosed with high blood sugar levels. They will be compared with a group of healthy individuals who do not have diabetes but are of the same ethnic background. Participants can expect to go through several steps, including providing blood and urine samples, answering questions about their health, and undergoing tests like blood pressure measurements and eye exams. The study is currently recruiting participants and aims to gather important insights that could benefit diabetes care in the future.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • As our primary interest is in T2D, it is important to exclude individuals who may have diabetes of another etiology. Elevated blood glucose in individuals 25 years old or younger is unlikely (in West Africa) to result from T2D and may reflect Type 1 Diabetes. Therefore, only individuals older than 25 years will be included in this study.
• • We are seeking to enroll persons without T2D or with previously or newly diagnosed T2D. Previously diagnosed cases will be determined by self-report of being treated with oral medication or insulin. Newly diagnosed cases will be determined by fasting blood glucose value \>= 126 mg/dl on more than one occasion. Individuals who have elevated blood glucose during their initial reading will be asked to return to the study site for a second test. If this test also has a fasting blood glucose value \>= 126 mg/dl, then they will be considered a new case. The control group will be individuals with no report of T2D diagnosis and fasting plasma glucose (FPG)\< 126 mg/dl.
• • Only unrelated individuals will be included in this phase of the study to avoid confounding genetic association studies by relatedness in the study population.
• EXCLUSION CRITERIA:
• An individual who meets any of the following criteria will be excluded from participation in this study:
• • Incarceration.
• • Lack capacity to consent to research participation.
• • Pregnancy.