Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes

Launched by BARTS & THE LONDON NHS TRUST · Jul 28, 2009

Keywords

ClinConnect Summary

This clinical trial is focused on developing a special test, called a biomarker panel, to help predict kidney problems earlier in patients with diabetes. People with diabetes are at a higher risk of kidney failure, especially when they undergo certain medical tests that use dye, like X-rays to check heart issues. By identifying those who might be more likely to have kidney complications, doctors hope to make these tests safer and more accessible for diabetes patients.

To be eligible for the trial, participants need to be at least 18 years old and diagnosed with diabetes, along with specific kidney function measurements. They should also be scheduled for a certain heart procedure called PCI (Percutaneous Coronary Intervention) and agree to provide some blood and urine samples for the study. Participants will be involved in monitoring their health and may help researchers gather important information that can lead to better care for future patients with diabetes. If you or someone you know is interested, please reach out to the study coordinators for more details!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age \> 18 years, known diabetes mellitus or BM on arrival consistent with probable diagnosis of diabetes, eGFR \<60 ml/min
• • 2. Undergoing a PCI procedure
• • 3. Agrees to the additional collection of blood and urine samples as outlined above
• • 4. Agrees to access of their clinical records for the collection of relevant medical data
• • 5. No history or signs of drug abuse
• • 6. Able to understand and sign the written Informed Consent Form
• • 7. Able and willing to follow the Protocol requirements
• Exclusion Criteria:
• • 1. Cardiogenic shock
• • 2. Pregnancy
• • 3. Patient on renal replacement therapy (haemodialysis/CAPD/renal transplant)
• • 4. Known clinically significant infection such as HIV, Hepatitis or TB
• • 5. Any patient determined not able to make a reasoned, informed consent prior to the planned interventional procedure