Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · Dec 14, 2009
Trial Information
Current as of September 03, 2025
Completed
Keywords
ClinConnect Summary
Purpose: To evaluate the treatment effects of topical insulin eye drops for promoting corneal epithelium wound healing in patients receiving pars planar vitrectomy (PPV) for diabetic retinopathy and penetrating keratoplasty.
Background: During PPV for diabetic retinopathy retinopathy and penetrating keratoplasty, removal of the edematous corneal epithelial layer was usually required in order to obtain a better surgical view1 or enhance the postoperative epithelial wound healing process. However, delayed epithelial healing was frequently found in these patients after surgeries. In addition,...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Diabetic patients with proliferative retinopathy receiving PPV
- • Patients qualified for penetrating keratoplasty
- • DM control blood sugar AC \< 200mg/dl
- • no limbus defect
- • no glaucoma before and after surgery
- • Patients willing to receive surgery, blood drawl and OPD follow up
- • no previous corneal epithelial defect or disease
- Exclusion Criteria:
- • Limbus defect
- • postsurgical use of other eye drops
- • incomplete eyelid closure
- • glaucoma
- • unable to be followed up postoperatively
- • poor visual acuity or poor prognostic visual acuity
- • corneoneuropathy
- • severe dry eye syndrome
- • pregnant
- • receive eye surgery within one month after the previous eye surgery
About National Taiwan University Hospital
National Taiwan University Hospital (NTUH) is a leading medical institution renowned for its commitment to advancing healthcare through innovative research and clinical trials. As a pioneer in medical education and patient care in Taiwan, NTUH integrates cutting-edge technology with comprehensive clinical expertise to facilitate groundbreaking studies across various medical fields. The hospital’s dedicated research team collaborates with local and international partners to enhance the understanding of diseases and improve treatment outcomes. By prioritizing patient safety and ethical standards, NTUH strives to contribute to the global medical community and foster advancements in healthcare practices.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Taipei, , Taiwan
Patients applied
Trial Officials
Wei-Li Chen, MD, PhD
Principal Investigator
National Taiwan University Hospital, department of Ophthalmology
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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