A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters
Launched by MAYO CLINIC · Feb 8, 2010
Trial Information
Current as of May 27, 2025
Completed
Keywords
ClinConnect Summary
This is a pilot study to compare the hemodynamic changes that occur during induction with a novel drug combination known as ketofol with that of propofol. Propofol and ketamine are widely used as induction agents and their effects on patient hemodynamics are well known. Many of these drug-induced changes are undesirable and when used alone sometimes lead to hemodynamic effects on opposite ends of the spectrum, ie. hypotension (propofol) and hypertension (ketamine). We will investigate the hemodynamic changes associated with this drug combination referred to as "ketofol" (ketamine/propofol a...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • American Society of Anesthesiologists (ASA) physical status I and II who are to undergo elective general, urologic, orthopedic, plastic, or gynecologic surgery.
- Exclusion Criteria:
- • patients with age less than 18 yr or over 60 yr,
- • emergency surgery,
- • patients undergoing neurosurgical procedures,
- • any procedure with adjunctive analgesia,
- • any patient on chronic opiate use,
- • females who are known to be pregnant,
- • patients who had ingested psychotropic or sedative medication within one month of investigation,
- • patients with personality disorders,
- • weight greater than 20% of ideal, and
- • any known contraindications to ketamine or propofol.
About Mayo Clinic
Mayo Clinic is a renowned nonprofit medical practice and research institution dedicated to providing comprehensive healthcare and advancing medical knowledge through innovative research and education. With a commitment to patient-centered care, Mayo Clinic conducts numerous clinical trials aimed at exploring new therapies and improving treatment outcomes across various disciplines. Leveraging a multidisciplinary approach, the institution collaborates with leading experts and cutting-edge technology to ensure rigorous scientific standards and ethical practices in all its research endeavors. Through its trials, Mayo Clinic seeks to translate breakthroughs in science into tangible benefits for patients, fostering advancements in medicine that enhance health and quality of life.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Lebanon, New Hampshire, United States
Patients applied
Trial Officials
Nathan J Smischney, MD
Principal Investigator
Mayo Clinic
Matthew Koff, MD
Study Director
Dartmouth-Hitchcock Medical Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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