Continuous Hemodialysis With an Enhanced Middle Molecule Clearance Membrane

Launched by FRESENIUS MEDICAL CARE FRANCE · Feb 10, 2010

Keywords

ClinConnect Summary

In sepsis, the removal of middle molecular weight molecules such as cytokines (also called blood purification), has shown a great interest in intensive care during the last decades. Indeed, these cytokines are involved in the development of the multi-organ failure syndrome when patients are in septic shock. There is some evidence to suggest that extracorporeal therapies (hemofiltration-hemodialysis)are interesting tools to modulate the inflammatory response and to restore the immune homeostasis.

However, hemodialysis using "conventional" membranes does not allow the removal of middle molec...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Male or female aged over 18 years.
• • ICU patients with septic shock and AKI requiring continuous renal replacement.
• • Patient able to agree to be enrolled in the study with informed consent. If the patient can not provide consent, only the consent of family members will be sought if they are present and, to default, the opinion of trustworthy person under article L.1111-6 of the French Health Code. If there is no family present, or trustworthy person designated, the subject will not be included in the study.
• Exclusion Criteria:
• • Pregnancy or lactation.
• • Participation in another research protocol.
• • People particularly vulnerable as defined in Articles L.1121-5, L.1121-6, L.1121-7, L.1121-8 et L.1122-1-2 of the French Health Code.