Clinical Efficacy of 10% Arginine Bicarbonate Prophylaxis Paste

Launched by COLGATE PALMOLIVE · Feb 9, 2010

Keywords

ClinConnect Summary

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male and female subjects, ages 18-70, inclusive.
• • Availability for the three (3) week duration of the study.
• • Two (2) sensitive teeth, which must be anterior to the molars, and demonstrate cervical erosion/abrasion or gingival recession.
• • Qualifying response to tactile stimuli (Yeaple probe) as defined by a score between 10-50gms. of force.
• • Qualifying response to the air blast stimuli as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale.
• • Subjects need to satisfy the qualifying response to stimuli for both the parameters assessed (tactile or air) on two teeth to be entered into the study.
• • Good general health with no known allergies to products being tested.
• • Use of a non-desensitizing dentifrice for three months prior to entry into the study.
• • Signed Informed Consent Form.
• Exclusion Criteria:
• • Gross oral pathology, chronic disease, or history of allergy to test products.
• • Advanced periodontal disease or treatment for periodontal disease (including surgery) within the past twelve months.
• • Scheduled dental prophylaxis within three weeks prior to the Baseline Hypersensitivity Examination.
• • Sensitive teeth with mobility greater than one.
• • Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures.
• • Subjects that began to take anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, or daily analgesics within one month prior to the start of the study or who have to start taking these during the course of the study.
• • Participation in a desensitizing dentifrice study or regular use of a desensitizing dentifrice within the past three months.
• • Current participation in any other clinical study.
• • Pregnant or lactating subjects.
• • Allergies to oral care products, personal care consumer products, or their ingredients.
• • Medical condition which prohibits not eating/drinking for 4 hours.