SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.

Launched by RADBOUD UNIVERSITY MEDICAL CENTER · Mar 30, 2010

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Eligibility criteria

• Inclusion Criteria:
• • Legally capacitated;
• • ≥ 18 years of age;
• • Diagnosed with hypertension that is difficult to treat (blood pressure \> 140/90 mmHg in spite of two antihypertensive drugs in adequate doses), or accompanied by hypokalemia, either spontaneous or induced by use of diuretics;
• • patients must have a positive result on a sodium loading test (as recommended in the Endocrine Society Guideline), i.e. insufficient suppression of aldosterone.
• • Cooperating patient who is willing to undergo adrenal surgery in case of an adenoma or lateralized aldosterone secretion, who is able to comply with the study protocol and who is willing to give written informed consent.
• Exclusion Criteria:
• • Unsuitability for or objection to undergo AVS, CT or adrenal surgery.(including pregnancy);
• • Glucocorticoid remediable aldosteronism or adrenal carcinoma;
• • Severe or terminal co-morbidity which seriously interferes with possible treatment or health related quality of life;
• • Requirement of certain medication that interacts with the prescribed treatments in this protocol or that can cause hypertension as an important side-effect e.g. glucocorticoids. Patients will only be excluded as the medication cannot be stopped or altered.