Observe Change of Endotoxaemia and Related Mediators in Patients With Chronic Hepatitis B Virus (HBV) Infection
Launched by SUN YAT-SEN UNIVERSITY · Apr 19, 2010
Trial Information
Current as of July 21, 2025
Completed
Keywords
ClinConnect Summary
1. Patients Patients with chronic HBV infection and healthy volunteers were enrolled. There were asymptomatic carriers group, patients with chronic hepatitis, patients with hepatic cirrhosis, and patients with acute on chronic liver failure.
2. Endotoxin assay Blood samples were obtained under aseptic conditions by peripheral venipuncture and using pyrogen-free syringes, needles, and glassware. Plasma samples were heated at 70℃ for 10 min. Plasma concentration was then measured in duplicate using a commercially available Limulus amebocyte lysate assay following the manufacturer's protocol.
...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Chronic HBV infection
- • Diagnosis confirm to guideline of Chronic Hepatitis B and acute on chronic liver failure of the Asian Pacific Association for the Study of the Liver (APASL).
- Exclusion Criteria:
- • All the patients had no obvious mycotic infection, Gram-negative sepsis, or bacterial infection (except from the digestive system)
- • Infection of hepatitis A, C, D, or E virus
- • Autoimmune liver disease
- • Alcoholic liver disease
- • Metabolic liver disease
- • Drug-induced liver injury
- • Parasitic disease of the hepatobiliary system
- • Malignancy
- • Serious exacerbation of cardiovascular and respiratory system diseases
About Sun Yat Sen University
Sun Yat-sen University, a prestigious institution located in Guangzhou, China, is dedicated to advancing medical research and healthcare innovations. As a leading clinical trial sponsor, the university leverages its extensive academic resources and collaboration with top-tier medical professionals to conduct rigorous clinical studies. Committed to improving patient outcomes and contributing to global health knowledge, Sun Yat-sen University focuses on a wide range of therapeutic areas, employing cutting-edge methodologies to ensure the integrity and efficacy of its research initiatives. Through its clinical trials, the university aims to foster scientific advancements and enhance the quality of care provided to patients both locally and internationally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Guangzhou, Guangdong, China
Patients applied
Trial Officials
Gao Zhiliang, Professor
Study Chair
The Third Affliated Hospital of Sun Yat-sen University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials