Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures
Launched by ATTIKON HOSPITAL · Apr 20, 2010
Trial Information
Current as of June 25, 2025
Completed
Keywords
ClinConnect Summary
Atrial fibrillation (AF) is the single most common post-operative complication after on-pump cardiac surgery, ranging from roughly 25% in CABG procedures, up to 65% in valve replacement procedures. The presence of AF in cardiac surgery patients doubles the morbidity amongst these patients, as well as raising the mortality rates. VitC is an electron donor for a number of enzymatic systems, reducing potentially harmful free radicals. In post-procedural AF, there is increased peroxynitrite concentration, which is a target for vitamin C. A randomized, double blind study will be conducted in ord...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients undergoing on-pump cardiac surgery
- Exclusion Criteria:
- • Off-pump cardiac surgery procedure
- • AF before the procedure
- • Recent infection and/or infectious endocarditis
- • Presence of neoplasia
- • Chronic renal failure with creatinine\>2.3 mg/dl
- • Hepatic failure
- • Autoimmune disease and/or disease that brings about a systematic inflammatory response
- • Thyroid disease
- • Systematic use of supplements that contain vitC or carnitine
- • The use of NSAIDs other than aspirin for a time period up to one month before the procedure
About Attikon Hospital
Attikon Hospital is a leading medical institution dedicated to advancing healthcare through innovative clinical research. With a strong commitment to patient-centered care, the hospital actively sponsors clinical trials that aim to evaluate new therapeutic interventions and improve treatment outcomes across various medical fields. Attikon Hospital leverages its state-of-the-art facilities and a multidisciplinary team of experienced healthcare professionals to ensure rigorous study design, ethical standards, and comprehensive patient safety. By fostering collaboration among researchers, clinicians, and patients, Attikon Hospital plays a pivotal role in translating scientific discoveries into effective clinical practices.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Athens, , Greece
Patients applied
Trial Officials
Ioannis Toumpoulis, MD
Study Chair
University of Athens Medical School, Attikon Hospital, Cardiology Department
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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