Comparison of Synera Patch Versus LMX-4 Cream Versus Placebo Patch for Pain Reduction During Venipuncture in Children

Launched by CAROL MORREALE · May 3, 2010

Keywords

ClinConnect Summary

This study will compare the effectiveness of a patch applied for 30 minutes (Synera-lidocaine 70 mg/tetracaine 70 mg) with the effectiveness of a cream (LMX-4- 4% liposomal lidocaine) and a placebo patch applied for the same length of time in reducing pain due to needle sticks in children. One hundred fifty children and adolescents 5-17 years old admitted to emergency department or presenting to the phlebotomy lab. will be randomly placed in each group. Children will rate their level of pain using the Faces Pain Scale-Revised (FPS-R) before the medication is applied, after the medication is...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children requiring venipuncture for medical care
• • The ability to demonstrate proper understanding of the Faces Pain Scale-Revised (FPS-R)
• • Parents of enrolled children need to be present during the procedure and be willing to rate their child's pain
• Exclusion Criteria:
• • Damaged or inflamed skin at the designated application site
• • Known sensitivity to components of Synera or LMX-4 (lidocaine, tetracaine, or local anesthetics of the amide or ester type, PABA derivatives)
• • Contraindications to Synera or LMX-4 use (severe hepatic disease, history of drug-induced methemoglobinemia, taking Class 1 antiarrhythmics)
• • Use of analgesics during the past 24 hours
• • Teenage female participants who are pregnant or lactating
• • If in the attending's judgment the patient cannot wait wait 30 minutes for a blood drawn. These conditions include but are not limited to: sepsis, trauma, surgical emergencies, severe dehydration.