Childhood Cancer Survivor Study

Launched by ST. JUDE CHILDREN'S RESEARCH HOSPITAL · May 7, 2010

Keywords

ClinConnect Summary

The Childhood Cancer Survivor Study (CCSS) is a research project that aims to understand the long-term effects of cancer and its treatments on young people who survived cancer. This study will look at about 50,000 survivors who were diagnosed with cancer before they turned 21, between 1970 and 1999, and it will also include 10,000 of their siblings as a comparison group. The researchers want to learn more about how treatments like chemotherapy, radiation, and surgery might lead to health problems later in life for these survivors.

To be eligible, participants need to have survived specific types of cancer, such as leukemia or lymphoma, for at least five years after their diagnosis. They should have been diagnosed before turning 21 years old and should speak either English or Spanish while living in the U.S. or Canada at the time of their diagnosis. Participants will be asked about their health and experiences after treatment, which will help researchers identify any late health issues that may arise. This study is important because it can provide insights that help improve the care and support for childhood cancer survivors in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Initial Cohort:
• • Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.
• Expanded cohort:
• • Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
• • English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.
• Exclusion Criteria:
• • Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
• • Non-English speaking or residence outside the US or Canada.
• Sibling Controls:
• • For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.