A Study to Compare the Effectiveness of Two Different Outpatient Endometrial Ablation Techniques Used for Heavy Periods

Launched by BIRMINGHAM WOMEN'S NHS FOUNDATION TRUST · May 14, 2010

Keywords

ClinConnect Summary

Heavy menstrual bleeding (HMB) or 'menorrhagia' is a common condition with a major impact on health-related quality of life and health resource utilization in both primary and secondary care. In over 50% of cases no organic pathology is present and the term dysfunctional uterine bleeding (DUB) is used. First line treatment of DUB is medical and where this fails, surgery is indicated using either minimally invasive approaches (endometrial ablation) or major surgery (hysterectomy). Endometrial ablation has been extensively evaluated against the gold standard of hysterectomy and shown to be ef...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women with no desire to preserve their fertility who have heavy menstrual bleeding without organic pathology (DUB) of more than six months duration
• • Premenopausal follicular follicle stimulating hormone (FSH) level of less than 40 IU/L.
• • Associated functional disability (negative impact on life quality).
• • Lack of response to medical treatment.
• • Prepared to undergo surgical treatment without general anaesthesia
• Exclusion Criteria:
• • Women under 25 years
• • Suspected genital tract infection
• • Uterine pathology including endometrial pathology on endometrial biopsy (e.g. endometrial hyperplasia or carcinoma) and structural lesions (e.g. uterine malformations, adhesions, polyps, submucous fibroids or extracavity fibroids \> 3cm in diameter) as identified on pelvic ultrasound and/or outpatient hysteroscopy.
• • Uterine cavity length \>11cm
• • Adnexal pathology
• • Previous open myomectomy or endometrial ablation / resection and classical caesarian section
• • patients considered vulnerable (e.g. current mental illness, emotionally labile, learning difficulties, immaturity)