Pilot Study to Evaluate the Contribution of Gene Variants to Idiopathic Urolithiasis

Launched by MAYO CLINIC · May 20, 2010

Keywords

ClinConnect Summary

Nephrolithiasis occurs in approximately 1 in 10 individuals in the United States with increasing prevalence noted over the past three decades (ref: Worcester E, Coe F. Nephrolithiasis. Prim Care Clin Office Pract 35 (2008) 369-391). Recurrence is common - occurring in more than 50% of these patients, many of whom require surgical intervention. An estimated 5-6 billion dollars a year is spent on the treatment of kidney stones. Symptoms of kidney stones include flank pain, blood in the urine, and nausea and vomiting. Beyond acute attacks associated with considerable morbidity and cost, recent...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Cases:
• • History of calcium oxalate stones
• • 18 years of age or older
• • Willing to provide a blood sample, and questionnaire
• Controls:
• • 18 years of age or older
• • No personal history of urolithiasis
• • Willing to provide a blood sample and questionnaire
• Exclusion Criteria:
• Cases:
• • Secondary causes of urolithiasis including: Bowel disease, Renal tubular acidosis, hyperparathyroidism