Renal Effect of Pentoxyphylline in High Risk Patients Undergoing Angiography

Launched by MEIR MEDICAL CENTER · Jun 14, 2010

Keywords

ClinConnect Summary

Impairment of renal function following exposure to intravenous radio-graphic contrast materials is the third major cause of renal hospital acquired renal dysfunction. Renal dysfunction occurs most often in patients with chronic renal failure and or patients with diabetes mellitus and contributes to the morbidity and mortality. Previous research work proved that the use volume expansion with N-acetyl cysteine (NAC) is superior to volume expiation alone to prevent renal impairment due to radio-contrast5. NAC a potent anti oxidant may prevent CIN by stopping direct oxidative tissue damage and ...

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Eligibility criteria

• Inclusion Criteria:
• Cardiology patients:
• • 1. Hospitalization for ACS (acute coronary syndrome) with NSTEMI or Unstable Angina
• • 2. Diabetic patients (treated with insulin or oral hypoglycemic drugs) or patients with basal serum creatinine greater than 1.3mg/dl in females and 1.5 mg/dl in male patients.
• • 3. Informed consent
• • 4. Age between 18-75
• Radiology patients:
• • 1. Radiology patients should be diabetic patients (treated with insulin or oral hypoglycemic drugs) or patients with basal serum creatinine of 1.3mg/dl in females and 1.5 mg/dl in male patients.
• • 2. Informed consent
• • 3. Age between 18-75