Efficacy and Tolerability of Escitalopram and Duloxetine in Outpatients With Major Depressive Disorder

Launched by H. LUNDBECK A/S · Jun 21, 2010

Keywords

ClinConnect Summary

Depression is a common mental disorder that presents with depressed mood, loss of interest or pleasure, disturbed sleep or appetite, low energy, feelings of guilt or low self-worth, and poor concentration. The lifetime prevalence of Major Depressive Disorder (MDD) in community samples is 10-25% for women and 5-12% for men. Depression may become chronic or recurrent and lead to substantial impairments in an individual's ability to take care of his or her everyday responsibilities. At its worst, depression may lead to suicide. Depression is recurrent in 75-80% of patients and becomes chronic ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The patient suffers from a primary diagnosis of MDD according to DSM-IV-TR criteria (classification code 296.xx; current episode assessed using the MINI)
• • The patient has a MADRS total score \>=26 and a CGI-S score \>=4 at the Baseline Visit
• Exclusion Criteria:
• • Any current psychiatric disorder other than MDD as defined in the DSM-IV TR
• • Female patients of childbearing potential who are not using effective contraception
• • Use of any psychoactive medication 2 weeks prior to screening and during the study
• • Other protocol-defined inclusion and exclusion criteria may apply.