The Role of GLP-1 in Satiety Perception in Humans

Launched by UNIVERSITY OF WASHINGTON · Jun 25, 2010

Keywords

ClinConnect Summary

Many times each day, we see food or representations of food and evaluate whether or not the food looks good to us. If it does, we then balance external factors, such as the social situation or time of day, against internal signals about our hunger state in order to decide what and when to eat. However, recent functional magnetic resonance imaging (fMRI) studies suggest that internal signals, such as hormones regulating appetite and satiety, govern our food intake in part by acting on neural circuits to affect whether a given food appears appetizing at that moment. In addition, photographs o...

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Eligibility criteria

• Inclusion Criteria:
• • 1. Male or female between 18-29 years of age
• • 2. BMI between 18.5-24.9 kg/m2
• • 3. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
• Exclusion Criteria:
• • 1. Chronic health conditions, including diabetes and kidney disease.
• • 2. Current dieting for weight loss or restrained eating
• • 3. History of obesity, eating disorders, or weight loss surgery
• • 4. Random blood glucose \>140
• • 5. Pregnancy or use of oral contraceptives
• • 6. Current smoker
• • 7. Recreational drug use or alcohol use of \> 1 drink per day for females, \> 2 per day for males
• • 8. Food allergy or intolerance to study foods.
• • 9. Medications known to alter appetite (e.g., amphetamines, atypical antipsychotics) or gastric emptying (e.g., metoclopromide)
• • 10. Contraindications to MRI, such as implanted metal or claustrophobia.
• • 11. Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.