Latency in Pulmonary Tuberculosis

Launched by TUBERCULOSIS RESEARCH CENTRE, INDIA · Jun 30, 2010

Keywords

ClinConnect Summary

Although Mycobacterium tuberculosis (Mtb) infects approximately 2 billion people worldwide, 90% of Mtb infected individuals are able to resist overt disease (active tuberculosis) development and manifest only latent infection. Latent tuberculosis (TB) is defined as the persistent presence of live Mtb within an infected host without causing disease. It is characterized by a delayed type hypersensitivity response to purified protein derivative (PPD) mediated by mycobacteria specific T cells. During latency, Mtb is contained in localized granulomas where the mycobacteria reside in macrophages ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 years and above
• • Residing in or around Chennai or Madurai
• • No anti-TB treatment in the past or should have had less than one month of treatment (but less than one week in the preceding one month before enrollment in the study)
• • At least two sputum smears should be positive for tubercle bacilli by fluorescent microscopy
• • Express willingness to attend the treatment centre for supervised treatment
• • Express willingness for home visits by the staff of the centre
• • Express willingness to give written informed consent
• Exclusion Criteria:
• • Body weight less than 30 kg
• • Hepatic or renal disease as evidenced by clinical or biochemical abnormalities
• • Diabetes mellitus
• • A history of seizure or loss of consciousness
• • Psychiatric illness
• • An abnormal electrocardiogram or anti-arrhythmic medication
• • Those in a moribund state
• • Sero-positive for HIV antibodies
• • Pregnancy or lactation
• • Visual disorders other than refractory error