Comparison of Intravenous Injection of Calcium Antagonist and Beta-blockade on Endothelial Shear Stress of Coronary Artery

Launched by NANJING MEDICAL UNIVERSITY · Jul 28, 2010

Keywords

ClinConnect Summary

Blood flow-induced endothelial shear stress has strong effect on endothelial function and development or progression of plaque formation. It is extensively accepted that low and/or oscillating shear stress causes endothelial dysfunction and is one of crucial factors in localizing early atherosclerosis .In contrary, normal and high shear stress is atheroma protective and is involved in compensatory remodeling . Most studies reported that the endothelial shear stress distribution in often idealized geometrical models of human coronary arteries was the subject of numerous investigations , and ...

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Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of unstable angina and non-Q wave myocardial infarction
• • Age 18-75 yr.
• • Diameter stenosis of coronary artery\<70% diameter stenosis by visual estimation
• • Blood pressure \>110/70 mmHg
• • Heart rate 60-\~100 bpm, No cardiac arrhythmias
• Exclusion Criteria:
• • St-elevation myocardial infarction
• • Lower blood pressure(\<100/70mmHg)
• • Heart rate \<60 or \>100 bpm, The presence of cardiac arrhythmias
• • Allergy to study drugs
• • Women in pregnancy
• • Liver dysfunction
• • Creatinine \>2.5mg/dl
• • Bleeding stroke within 6 months
• • Left ventricular ejection fraction\<30% before maximal medication