Telomere and Telomerase
Launched by UNIVERSITY OF KANSAS MEDICAL CENTER · Aug 4, 2010
Trial Information
Current as of August 02, 2025
Withdrawn
Keywords
ClinConnect Summary
A telomere is a region of repetitive DNA at the end of chromosomes, which protects the end of the chromosome from destruction. Telomeres can be viewed as the tips on the ends of shoelaces that keep them from unraveling. Telomeres compensate for incomplete semi-conservative DNA replication at chromosomal ends. In absence of a reparative process, DNA sequences would be lost in every replicative phase until they reached a critical level, at which point cell division would stop.
Loss of telomeres leads to chromosome end-to-end fusion, chromosome re-arrangements, and genome instability.
Telome...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Diagnosis of advanced Myelodysplastic Syndrome (MDS) or acute myeloid leukemia
- • must be 18 years of age
- • must be able to give written informed consent
About University Of Kansas Medical Center
The University of Kansas Medical Center (KUMC) is a leading academic medical institution dedicated to advancing healthcare through innovative research, education, and clinical practice. As a prominent clinical trial sponsor, KUMC leverages its extensive expertise in diverse medical fields to conduct rigorous clinical research aimed at improving patient outcomes and developing new treatment modalities. With a commitment to ethical standards and patient safety, KUMC collaborates with multidisciplinary teams to facilitate groundbreaking studies that address significant health challenges, ultimately contributing to the advancement of medical knowledge and the enhancement of community health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Westwood, Kansas, United States
Patients applied
Trial Officials
Siddhartha Ganguly, MD
Principal Investigator
University of Kansas Medical Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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