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Search / Trial NCT01178931

Dydrogesterone Versus Intravaginal Progesterone in the Luteal Phase Support

Launched by UNIVERSITY OF ZAGREB · Aug 9, 2010

Trial Information

Current as of July 24, 2025

Completed

Keywords

Ivf Luteal Phase Support Oral Progesterone Vaginal Progesterone Pregnancy Rate Safety Tolerability

ClinConnect Summary

The use of gonadotropin-releasing hormone (GnRH) agonists in the ovarian stimulation, which prevents a premature surge of luteal hormone (LH), ultimately leads to suppression of the pituitary gland and high levels of estrogen observed during induced cycles result in inhibiting effect on the implantation of human embryos.

The luteal support in in-vitro-fertilization (IVF) cycles can be prolonged using human chorion gonadotropin(hCG) and/or progesterone.

Since it has been noted that the use of hCG was related with higher risks of the onset of ovarian hyperstimulation syndrome (OHSS), proges...

Gender

FEMALE

Eligibility criteria

  • Inclusion Criteria:
  • routine ovulation induction protocol with GnRH agonist
  • less than three prior IVF cycles
  • at least three aspirated oocytes
  • BMI \<35 kg/m2
  • age \<45 years
  • Exclusion Criteria:
  • history of dysfunctional uterine bleeding
  • acute urogenital disease
  • recurrent miscarriage
  • previous allergic reactions to a progesterone products

About University Of Zagreb

The University of Zagreb, a leading academic institution in Croatia, is committed to advancing medical research and improving healthcare outcomes through innovative clinical trials. With a focus on interdisciplinary collaboration, the university harnesses its extensive expertise and state-of-the-art facilities to conduct rigorous clinical studies that address pressing health challenges. By fostering partnerships with healthcare professionals, industry leaders, and regulatory bodies, the University of Zagreb aims to translate scientific discoveries into practical applications, ultimately enhancing patient care and contributing to the global body of medical knowledge.

Locations

Zagreb, , Croatia

Patients applied

0 patients applied

Trial Officials

Jozo Tomic, M.D.

Principal Investigator

Department of Human Reproduction, University Hospital Center Sisters of Mercy

Vlatka Tomic, M.D.

Study Chair

Department of Human Reproduction, University Hospital Center Sisters of Mercy

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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