Treatment of Non Union of Long Bone Fractures by Autologous Mesenchymal Stem Cell
Launched by ROYAN INSTITUTE · Sep 20, 2010
Trial Information
Current as of June 24, 2025
Completed
Keywords
ClinConnect Summary
Treatment of nonunion, delayed union and malunion fractures of long bones remains problematic. The definition of nonunion is a failure of the fracture to heal in six months in a patient in whom progressive repair had not been observed radiographically between the third and sixth month after the fracture. Nonunion is a serious complication of a fracture, occurring in 2-10% of patients, as it is associated with high economic and health burden. Many cases are subsequently approached by multiple surgical and nonsurgical modalities. Various devices, under the name of "bone growth stimulators" ha...
Gender
ALL
Eligibility criteria
- * Inclusion criteria:
- • Both genders are eligible
- • Nonunion or delayed union diagnosed with X-Ray examination.
- • More than 4 cm distance to joint
- • Provided written informed consent
- * Exclusion criteria:
- • Multiple major fracture or untreated major fracture
- • Infected fracture
- • HIV, hepatitis B or hepatitis C infection at the time of screening
- • Pregnant or lactating women
- • Diagnosis of cancer
- • Active treatment with immunosuppressive drugs or anticoagulant agent
- • Known allergic reaction to components of study treatment and/or study injection procedure
About Royan Institute
The Royan Institute is a leading research organization dedicated to advancing the fields of reproductive health, stem cell biology, and regenerative medicine. Established to promote scientific innovation and clinical applications, the Institute focuses on translating cutting-edge research into therapeutic solutions. With a strong commitment to ethical practices and collaboration, Royan Institute conducts rigorous clinical trials aimed at improving patient outcomes and enhancing healthcare practices globally. Through its multidisciplinary approach and state-of-the-art facilities, the Institute strives to push the boundaries of medical science and contribute significantly to the understanding and treatment of complex health issues.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Tehran, , Iran, Islamic Republic Of
Patients applied
Trial Officials
Hamid Gourabi, PhD
Study Chair
President of Royan Institute
Mohammad reza Baghban Eslami Nejad, PhD
Study Director
Sientific Board
Mohssen Emadeddin, MD
Principal Investigator
Orthopadic Investigator
Nasser Aghdami, MD,PhD
Principal Investigator
Head of Regenerative center
Ahmad Vosough, MD
Principal Investigator
Radiologist investigator
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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