Paracétamol PMB by Sublingual et Buccal Routes

Launched by UNIVERSITY HOSPITAL, CLERMONT-FERRAND · Sep 21, 2010

Keywords

ClinConnect Summary

Crossover study, double-blind, randomized, controlled versus placebo.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy volunteers.
• • Aged over 18 years and not more than 50 years.
• • Males or female
• * Values of vital signs before administration of the test products:
• • PAS between 100-140 mm Hg
• • PAD between 50-90 mm Hg
• • Radial pulse between 45-90 beats per minute
• • Free from any treatment in the 7 days preceding inclusion including no use of analgesics or anti-inflammatories
• Exclusion Criteria:
• • Contraindications to the administration of paracetamol
• • Medical history and / or surgical judged by the investigator or his representative as being incompatible with the test, especially subjects with neuropathic pain
• • Pathology evolutionary time of the review for inclusion.
• • Binge drinking, smoking (more than 10 cigarettes / day), coffee, tea or drinks containing caffeine (equivalent to more than 4 cups per day) or drug abuse.
• • Subject does not meet the selection criteria regarding their ability to discriminate the sensations resulting from noxious stimuli during psychometric testing.
• • Topic having all breaches of the oral mucosa (aphtes. ..).