Extended High Dose Letrozole Regimen Versus Short Low Dose Letrozole Regimen as an Adjuvant to GnRH Antagonist Protocol in the Management of Poor Responders Undergoing IVF-ET
Launched by CAIRO UNIVERSITY · Oct 12, 2010
Trial Information
Current as of April 25, 2025
Completed
Keywords
ClinConnect Summary
Poor response to controlled ovarian stimulation (COH) is estimated to occur in 9-24 % of all IVF cycles. Although there is no consensus on the definition of poor response to COH, inability to produce adequate number of mature follicles( ≤ 2-5) or to recruit adequate number of oocytes ( ≤ 3 oocytes ) in response to standard stimulation protocols are the main criteria used for diagnosis of poor responders .
Patients with poor response to COH usually have higher cyclical cancelation rate , poor embryo quality and less number of embryos suitable for transfer or cryopreservation .
During the p...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Patients who produced less than three mature follicles in response to standard GnRH agonist long protocol in their first IVF cycle
- Exclusion Criteria:
- • Age \> 42 years
- • FSH\> 12 IU/L
- • Irregular menstrual cycles
- • Unilateral ovary
- • Polycystic ovary syndrome
- • Endometriosis
- • Male factor of infertility requiring ICSI
- • History of recurrent miscarriage
- • Endocrinologic disorders
- • Systemic disease contraindicating pregnancy
About Cairo University
Cairo University, a premier institution in Egypt, is dedicated to advancing medical research and education through innovative clinical trials. With a strong emphasis on improving healthcare outcomes, the university collaborates with various stakeholders to conduct rigorous scientific studies that address critical health challenges. Leveraging its extensive resources and expert faculty, Cairo University aims to contribute valuable insights to the medical community and enhance patient care both locally and globally. Through its commitment to ethical research practices and excellence, the university plays a pivotal role in shaping the future of healthcare in the region.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Giza,, , Egypt
Patients applied
Trial Officials
Usama M Fouda, M.D, PhD
Study Chair
Cairo University
Ahmed M Sayed, M.D, PhD
Study Director
Cairo University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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