Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

Launched by NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) · Dec 23, 2010

Keywords

ClinConnect Summary

This clinical trial is focused on developing and improving special imaging techniques called magnetic resonance spectroscopy (MRS) that can help scientists better understand the chemistry of the brain and muscles. By using these advanced MRI methods, researchers hope to gain insights that could lead to new treatments for psychiatric illnesses. The study is looking for healthy volunteers between the ages of 18 and 65 who can help with this important research.

If you decide to participate, you'll first go through a screening visit where your health will be assessed through a medical examination and some tests. If you qualify, you'll return for a second visit to have an MRI scan of your brain, which can provide detailed images of brain structure. If you've had an MRI in the last year, your previous images can be used instead. You'll also undergo an MRS scan, which looks at the chemical activity in your brain. This study is currently recruiting participants, so if you meet the criteria and are interested in contributing to brain research, this could be a great opportunity!

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • 18-65 years of age
• • able to give written informed consent
• • healthy based on medical history and physical exam
• • enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
• EXCLUSION CRITERIA:
• • Any current Axis 1 diagnosis
• • Clinically significant laboratory abnormalities
• • Positive HIV test
• • Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
• • History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
• • Inability to lie flat on camera bed for about two and a half hours
• • Pregnant or breastfeeding
• • Current substance use disorder based on DSM-5
• • NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.